Gray matter differences associated with menopausal hormone therapy in menopausal women: a DARTEL-based VBM study

Gray matter differences associated with menopausal hormone therapy in menopausal women: a DARTEL-based VBM study

  • Paciuc, J. Hormone therapy in menopause. Adv. Exp. Med. Biol. 1242, 89–120 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Takahashi, T. A. & Johnson, K. M. Menopause. Med. Clin. N. Am. 99, 521–534 (2015).

    Article 

    Google Scholar
     

  • Baber, R. J., Panay, N. & Fenton, A. 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy. Climacteric 19, 109–150 (2016).

    Article 
    CAS 

    Google Scholar
     

  • Palacios, S., Stevenson, J. C., Schaudig, K., Lukasiewicz, M. & Graziottin, A. Hormone therapy for first-line management of menopausal symptoms: Practical recommendations. Womens Health 15, 1745506519864009 (2019).

    CAS 

    Google Scholar
     

  • Kim, T. H., Kang, H. K., Park, K. & Jeong, G. W. Localized brain metabolite changes during visual sexual stimulation in postmenopausal women: A pilot study using functional magnetic resonance spectroscopy. Menopause 21, 59–66 (2014).

    Article 

    Google Scholar
     

  • Kim, G. W., Park, K. & Jeong, G. W. Effects of sex hormones and age on brain volume in post-menopausal women. J. Sex. Med. 15, 662–670 (2018).

    Article 

    Google Scholar
     

  • Rahman, A. et al. Sex and gender driven modifiers of Alzheimer’s: The role for estrogenic control across age, race, medical, and lifestyle risks. Front. Aging Neurosci. 11, 315 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Hagemann, G. et al. Changes in brain size during the menstrual cycle. PLoS ONE 6, e14655 (2011).

    Article 
    ADS 
    CAS 

    Google Scholar
     

  • Ossewaarde, L. et al. Menstrual cycle-related changes in amygdala morphology are associated with changes in stress sensitivity. Hum. Brain Mapp. 34, 1187–1193 (2013).

    Article 

    Google Scholar
     

  • Lisofsky, N. et al. Hippocampal volume and functional connectivity changes during the female menstrual cycle. Neuroimage 118, 154–162 (2015).

    Article 

    Google Scholar
     

  • Protopopescu, X. et al. Hippocampal structural changes across the menstrual cycle. Hippocampus 18, 985–988 (2008).

    Article 

    Google Scholar
     

  • Petersen, N., Touroutoglou, A., Andreano, J. M. & Cahill, L. Oral contraceptive pill use is associated with localized decreases in cortical thickness. Hum. Brain Mapp. 36, 2644–2654 (2015).

    Article 

    Google Scholar
     

  • De Bondt, T. et al. Regional gray matter volume differences and sex-hormone correlations as a function of menstrual cycle phase and hormonal contraceptives use. Brain Res. 1530, 22–31 (2013).

    Article 

    Google Scholar
     

  • Pletzer, B., Kronbichler, M. & Kerschbaum, H. Differential effects of androgenic and anti-androgenic progestins on fusiform and frontal gray matter volume and face recognition performance. Brain Res. 1596, 108–115 (2015).

    Article 
    CAS 

    Google Scholar
     

  • Albert, K. et al. Estrogen enhances hippocampal gray-matter volume in young and older postmenopausal women: A prospective dose-response study. Neurobiol. Aging 56, 1–6 (2017).

    Article 
    CAS 

    Google Scholar
     

  • Menopause Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause 29, 767–794 (2022).

    Article 

    Google Scholar
     

  • Hickey, M., Elliott, J. & Davison, S. L. Hormone replacement therapy. BMJ 344, e763 (2012).

    Article 

    Google Scholar
     

  • Song, Y. J. et al. The effect of estrogen replacement therapy on Alzheimer’s disease and Parkinson’s disease in postmenopausal women: A meta-analysis. Front. Neurosci. 14, 157 (2020).

    Article 
    ADS 

    Google Scholar
     

  • Ibrahim, A. W., Sodipo, O. A., Mshelia, I. A. & Machina, B. K. Hormone replacement therapy and Alzheimer’s disease in older women: A systematic review of literature. J. Neurosci. Behav. Health 10, 1–8 (2018).

    Article 
    CAS 

    Google Scholar
     

  • Savolainen-Peltonen, H. et al. Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: Nationwide case-control study. BMJ 364, l665 (2019).

    Article 

    Google Scholar
     

  • Gambacciani, M. et al. Menopause and hormone replacement therapy: The 2017 Recommendations of the Italian Menopause Society. Minerva Ginecol. 70, 27–34 (2018).


    Google Scholar
     

  • Nudy, M., Chinchilli, V. M. & Foy, A. J. A systematic review and meta-regression analysis to examine the “timing hypothesis” of hormone replacement therapy on mortality, coronary heart disease, and stroke. IJC Heart Vasc. 22, 123–131 (2019).

    Article 

    Google Scholar
     

  • Gambacciani, M., Cagnacci, A. & Lello, S. Hormone replacement therapy and prevention of chronic conditions. Climacteric 22, 303–306 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Goto, M. et al. 3 Tesla MRI detects accelerated hippocampal volume reduction in postmenopausal women. J. Magn. Reson. Imaging 33, 48–53 (2011).

    Article 

    Google Scholar
     

  • Boyle, C. P. et al. Estrogen, brain structure, and cognition in postmenopausal women. Hum. Brain Mapp. 42, 24–35 (2021).

    Article 

    Google Scholar
     

  • Resnick, S. M. et al. Postmenopausal hormone therapy and regional brain volumes: The WHIMS-MRI Study. Neurology 72, 135–142 (2009).

    Article 
    CAS 

    Google Scholar
     

  • Russell, J. K., Jones, C. K. & Newhouse, P. A. The role of estrogen in brain and cognitive aging. Neurotherapeutics 16, 649–665 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Boccardi, M. et al. Effects of hormone therapy on brain morphology of healthy postmenopausal women: A Voxel-based morphometry study. Menopause 13, 584–591 (2006).

    Article 

    Google Scholar
     

  • Lord, C., Buss, C., Lupien, S. J. & Pruessner, J. C. Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: A possible window of opportunity effect. Neurobiol. Aging 29, 95–101 (2008).

    Article 
    CAS 

    Google Scholar
     

  • Erickson, K. I. et al. Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy. Neurobiol. Aging 26, 1205–1213 (2005).

    Article 
    CAS 

    Google Scholar
     

  • Lord, C., Engert, V., Lupien, S. J. & Pruessner, J. C. Effect of sex and estrogen therapy on the aging brain: A voxel-based morphometry study. Menopause 17, 846–851 (2010).

    Article 

    Google Scholar
     

  • Kim, T. H., Kim, S. K. & Jeong, G. W. Cerebral gray matter volume variation in female-to-male transsexuals: A voxel-based morphometric study. NeuroReport 26, 1119–1125 (2015).

    Article 

    Google Scholar
     

  • Mott, N. N. & Pak, T. R. Estrogen signaling and the aging brain: Context-dependent considerations for postmenopausal hormone therapy. ISRN Endocrinol. 2013, 814690 (2013).

    Article 

    Google Scholar
     

  • Bustamante-Barrientos, F. A. et al. The impact of estrogen and estrogen-like molecules in neurogenesis and neurodegeneration: Beneficial or harmful?. Front. Cell. Neurosci. 15, 636176 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Fink, G., Sumner, B. E., Rosie, R., Grace, O. & Quinn, J. P. Estrogen control of central neurotransmission: Effect on mood, mental state, and memory. Cell. Mol. Neurobiol. 16, 325–344 (1996).

    Article 
    CAS 

    Google Scholar
     

  • Comasco, E., Frokjaer, V. G. & Sundström-Poromaa, I. Functional and molecular neuroimaging of menopause and hormone replacement therapy. Front. Neurosci. 8, 388 (2014).

    Article 

    Google Scholar
     

  • Khan, M. M., Dhandapani, K. M., Zhang, Q. G. & Brann, D. W. Estrogen regulation of spine density and excitatory synapses in rat prefrontal and somatosensory cerebral cortex. Steroids 78, 614–623 (2013).

    Article 
    CAS 

    Google Scholar
     

  • Bayer, U. & Hausmann, M. Hormone therapy in postmenopausal women affects hemispheric asymmetries in fine motor coordination. Horm. Behav. 58, 450–456 (2010).

    Article 
    CAS 

    Google Scholar
     

  • Maki, P. M. et al. Perimenopausal use of hormone therapy is associated with enhanced memory and hippocampal function later in life. Brain Res. 1379, 232–243 (2011).

    Article 
    CAS 

    Google Scholar
     

  • Maki, P. M. & Resnick, S. M. Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognition. Neurobiol. Aging 21, 373–383 (2000).

    Article 
    CAS 

    Google Scholar
     

  • Resnick, S. M., Maki, P. M., Golski, S., Kraut, M. A. & Zonderman, A. B. Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance. Horm. Behav. 34, 171–182 (1998).

    Article 
    CAS 

    Google Scholar
     

  • Neufang, S. et al. Sex differences and the impact of steroid hormones on the developing human brain. Cereb. Cortex 19, 464–473 (2009).

    Article 

    Google Scholar
     

  • Weiss, G., Skurnick, J. H., Goldsmith, L. T., Santoro, N. F. & Park, S. J. Menopause and hypothalamic-pituitary sensitivity to estrogen. JAMA 292, 2991–2996 (2004).

    Article 
    CAS 

    Google Scholar
     

  • Heffner, L. J. & Schust, D. J. The Reproductive System at a Glance 4th edn. (Wiley-Blackwell, 2014).


    Google Scholar
     

  • Ashburner, J. & Friston, K. J. Diffeomorphic registration using geodesic shooting and Gauss-Newton optimisation. Neuroimage 55, 954–967 (2011).

    Article 

    Google Scholar
     

  • Good, C. D. et al. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14, 21–36 (2001).

    Article 
    CAS 

    Google Scholar
     

  • Reddan, M. C., Lindquist, M. A. & Wager, T. D. Effect size estimation in neuroimaging. JAMA Psychiat. 74, 207–208 (2017).

    Article 

    Google Scholar