Racial disparities in breast cancer treatment patterns and treatment related adverse events
Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021).
Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2022. CA Cancer J. Clin. 72(1), 7–33 (2022).
Cancer of the Breast (Female)—Cancer Stat Facts [Internet]. SEER. [cited 2022 Jun 1]. https://seer.cancer.gov/statfacts/html/breast.html.
Waks, A. G. & Winer, E. P. Breast cancer treatment: A review. JAMA 321(3), 288–300 (2019).
Loibl, S., Poortmans, P., Morrow, M., Denkert, C. & Curigliano, G. Breast cancer. The Lancet 397(10286), 1750–1769 (2021).
Ewertz, M. & Jensen, A. B. Late effects of breast cancer treatment and potentials for rehabilitation. Acta Oncol. 50(2), 187–193 (2011).
Shapiro, C. L. & Recht, A. Side effects of adjuvant treatment of breast cancer. N. Engl. J. Med. 344(26), 1997–2008 (2001).
Paraskevi, T. Quality of life outcomes in patients with breast cancer. Oncol Rev. 6(1), e2 (2012).
Leclerc, A. F., Jerusalem, G., Devos, M., Crielaard, J. M. & Maquet, D. Multidisciplinary management of breast cancer. Arch. Public Health 74(1), 50 (2016).
Zavala, V. A. et al. Cancer health disparities in racial/ethnic minorities in the United States. Br. J. Cancer 124(2), 315–332 (2021).
Esnaola, N. F. & Ford, M. E. Racial differences and disparities in cancer care and outcomes: Where’s the rub?. Surg Oncol Clin N Am. 21(3), 417–viii (2012).
Gross, C. P., Smith, B. D., Wolf, E. & Andersen, M. Racial disparities in cancer therapy. Cancer 112(4), 900–908 (2008).
Iqbal, J., Ginsburg, O., Rochon, P. A., Sun, P. & Narod, S. A. Differences in breast cancer stage at diagnosis and cancer-specific survival by race and ethnicity in the United States. JAMA 313(2), 165–173 (2015).
Nahleh, Z. et al. Disparities in breast cancer: A multi-institutional comparative analysis focusing on American Hispanics. Cancer Med. 7(6), 2710–2717 (2018).
Rodriguez-Alcalá, M. E., Qin, H. & Jeanetta, S. The role of acculturation and social capital in access to health care: A meta-study on hispanics in the US. J. Commun. Health. 44(6), 1224–1252 (2019).
Parise, C. A., Bauer, K. R. & Caggiano, V. Variation in breast cancer subtypes with age and race/ethnicity. Crit. Rev. Oncol. Hematol. 76(1), 44–52 (2010).
Wheeler, S. B., Reeder-Hayes, K. E. & Carey, L. A. Disparities in breast cancer treatment and outcomes: Biological, social, and health system determinants and opportunities for research. Oncologist 18(9), 986–993 (2013).
Lund, M. J. et al. Parity and disparity in first course treatment of invasive breast cancer. Breast Cancer Res. Treat. 109(3), 545–557 (2008).
Pinheiro, L. C., Reshetnyak, E., Safford, M. M. & Kern, L. M. Racial disparities in preventable adverse events attributed to poor care coordination reported in a national study of older US adults. Med. Care. 59(10), 901–906 (2021).
Potentially Preventable Hospitalizations—United States, 2001–2009 [Internet]. [cited 2022 Jun 24]. https://www.cdc.gov/mmwr/preview/mmwrhtml/su6203a23.htm.
Bakullari, A. et al. Racial and ethnic disparities in healthcare-associated infections in the United States, 2009–2011. Infect. Control Hosp. Epidemiol. 35(S3), S10–S16 (2014).
Stabellini, N. et al. Sex differences in esophageal cancer overall and by histological subtype. Sci. Rep. 12(1), 5248 (2022).
Stabellini, N. et al. Sex differences in lung cancer treatment and outcomes at a large hybrid academic-community practice. JTO Clin. Res. Rep. 3(4), 100307 (2022).
Caisis | The Free & Open Source Cancer Data Management System [Internet]. [cited 2021 Apr 15]. http://www.caisis.org/.
EMERSE: Electronic Medical Record Search Engine [Internet]. [cited 2022 May 16]. https://project-emerse.org/index.html.
International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3) [Internet]. [cited 2021 Apr 15]. https://www.who.int/standards/classifications/other-classifications/international-classification-of-diseases-for-oncology.
Charlson, M. E., Pompei, P., Ales, K. L. & MacKenzie, C. R. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J. Chronic. Dis. 40(5), 373–383 (1987).
Giuliano, A. E., Edge, S. B. & Hortobagyi, G. N. Eighth edition of the AJCC cancer staging manual: Breast cancer. Ann. Surg. Oncol. 25(7), 1783–1785 (2018).
Makki, J. Diversity of Breast carcinoma: Histological subtypes and clinical relevance. Clin. Med. Insights Pathol. 21(8), 23–31 (2015).
HER2 Testing in Breast Cancer—2018 Focused Update [Internet]. College of American Pathologists. [cited 2022 Dec 11]. https://www.cap.org/protocols-and-guidelines/cap-guidelines/current-cap-guidelines/recommendations-for-human-epidermal-growth-factor-2-testing-in-breast-cancer.
Devlin, E. J., Denson, L. A. & Whitford, H. S. Cancer treatment side effects: A meta-analysis of the relationship between response expectancies and experience. J. Pain Symptom. Manag. 54(2), 245-258.e2 (2017).
RStudio | Open source & professional software for data science teams [Internet]. [cited 2022 May 3]. https://www.rstudio.com/.
von Elm, E. et al. Strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. BMJ 335(7624), 806–808 (2007).
Vince, R. A. et al. Reporting of racial health disparities research: Are we making progress?. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 40(1), 8–11 (2022).
Stanley, J., Harris, R., Cormack, D., Waa, A. & Edwards, R. The impact of racism on the future health of adults: Protocol for a prospective cohort study. BMC Public Health 19(1), 346 (2019).
Racism as a Determinant of Health: A Systematic Review and Meta-Analysis [Internet]. [cited 2022 Jan 21]. https://doi.org/10.1371/journal.pone.0138511
Williams, D. R. & Mohammed, S. A. Racism and health I: Pathways and scientific evidence. Am. Behav. Sci. 57(8), 1152–1173 (2013).
Jones, C. P. Confronting institutionalized racism. Phylon 1960 50(1/2), 7–22 (2002).
Paradies, Y. C. Defining, conceptualizing and characterizing racism in health research. Crit. Public Health 16(2), 143–157 (2006).
Krieger, N. Methods for the scientific study of discrimination and health: An ecosocial approach. Am. J. Public Health. 102(5), 936–944 (2012).
Jones, C. P. Invited commentary: “Race”, racism, and the practice of epidemiology. Am. J. Epidemiol. 154(4), 299–304 (2001).
SEER Cancer Statistics Review, 1975–2018 [Internet]. SEER. [cited 2022 Jun 26]. https://seer.cancer.gov/csr/1975_2018/index.html.
DeSantis, C. E. et al. Breast cancer statistics, 2019. CA Cancer J. Clin. 69(6), 438–451 (2019).
Daly, B. & Olopade, O. I. A perfect storm: How tumor biology, genomics, and health care delivery patterns collide to create a racial survival disparity in breast cancer and proposed interventions for change. CA Cancer J. Clin. 65(3), 221–238 (2015).
Stringer-Reasor, E. M., Elkhanany, A., Khoury, K., Simon, M. A. & Newman, L. A. Disparities in breast cancer associated With African American identity. Am. Soc. Clin. Oncol. Educ. Book Am. Soc. Clin. Oncol. Annu. Meet. 41, e29-46 (2021).
Pitt, J. J. et al. Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features. Nat. Commun. 9(1), 4181 (2018).
Goel, N. et al. Racial differences in genomic profiles of breast cancer. JAMA Netw. Open. 5(3), e220573 (2022).
Keenan, T. et al. Comparison of the genomic landscape between primary breast cancer in African American versus white women and the association of racial differences with tumor recurrence. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 33(31), 3621–3627 (2015).
Dietze, E. C., Sistrunk, C., Miranda-Carboni, G., O’Regan, R. & Seewaldt, V. L. Triple-negative breast cancer in African–American women: Disparities versus biology. Nat. Rev. Cancer. 15(4), 248–254 (2015).
Ansell, D. et al. A community effort to reduce the black/white breast cancer mortality disparity in Chicago. Cancer Causes Control CCC. 20(9), 1681–1688 (2009).
Press, R., Carrasquillo, O., Sciacca, R. R. & Giardina, E. G. V. Racial/ethnic disparities in time to follow-up after an abnormal mammogram. J. Womens Health 2002 17(6), 923–930 (2008).
Silber, J. H. et al. Characteristics associated with differences in survival among black and white women with breast cancer. JAMA 310(4), 389–397 (2013).
Li, C. I., Malone, K. E. & Daling, J. R. Differences in breast cancer stage, treatment, and survival by race and ethnicity. Arch. Intern. Med. 163(1), 49–56 (2003).
Griggs, J. J. et al. Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 25(18), 2522–2527 (2007).
Freedman, R. A., He, Y., Winer, E. P. & Keating, N. L. Trends in racial and age disparities in definitive local therapy of early-stage breast cancer. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 27(5), 713–719 (2009).
Griggs, J. J., Sorbero, M. E. S., Stark, A. T., Heininger, S. E. & Dick, A. W. Racial disparity in the dose and dose intensity of breast cancer adjuvant chemotherapy. Breast Cancer Res. Treat. 81(1), 21–31 (2003).
Bickell, N. A. et al. Missed opportunities: Racial disparities in adjuvant breast cancer treatment. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 24(9), 1357–1362 (2006).
Smith, K. et al. Ethnic disparities in adjuvant chemotherapy for breast cancer are not caused by excess toxicity in black patients. Clin. Breast Cancer 6(3), 260–266 (2005) (discussion 267–269).
Smith, G. L. et al. Racial disparities in the use of radiotherapy after breast-conserving surgery: A national medicare study. Cancer 116(3), 734–741 (2010).
Baehr, A., Peña, J. C. & Hu, D. J. Racial and ethnic disparities in adverse drug events: A systematic review of the literature. J. Racial. Ethn. Health Dispar. 2(4), 527–536 (2015).
Wright, C. B. et al. Race/ethnic disparities in mild cognitive impairment and dementia: The northern manhattan study. J. Alzheimers Dis. 80(3), 1129–1138 (2021).
Martino, S. C. et al. Racial/ethnic disparities in medicare beneficiaries’ care coordination experiences. Med. Care. 54(8), 765–771 (2016).
Hicks, L. S. et al. Is hospital service associated with racial and ethnic disparities in experiences with hospital care?. Am. J. Med. 118(5), 529–535 (2005).
Bach, P. B., Pham, H. H., Schrag, D., Tate, R. C. & Hargraves, J. L. Primary care physicians who treat blacks and whites. N. Engl. J. Med. 351(6), 575–584 (2004).
Hall, W. J. et al. Implicit racial/ethnic bias among health care professionals and its influence on health care outcomes: A systematic review. Am. J. Public Health 105(12), e60-76 (2015).
Shen, M. J. et al. The effects of race and racial concordance on patient-physician communication: A systematic review of the literature. J. Racial Ethn. Health Dispar. 5(1), 117–140 (2018).
Jatoi, I., Sung, H. & Jemal, A. The emergence of the racial disparity in U.S. breast-cancer mortality. N. Engl. J. Med. 386(25), 2349–2352 (2022).
Yedjou, C. G. et al. Health and racial disparity in breast cancer. Adv Exp Med Biol. 1152, 31–49 (2019).